Cyclosinone herbicide (often marketed as Cyclosinone Herbicide Granules) is a professional-grade, granular weed and brush killer designed to eliminate stubborn vegetation, persistent grasses, shrubs, and large trees from the root. Speed of Results: Begins working rapidly on contact, with visible yellowing or drying appearing within 24 to 48 hours to 7 days, and complete root decay or elimination within 15 days.